(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is identified as a dual-target PROTAC that is capable of inducing the ubiquitination and degradation of Smad3, while also elevating the protein level of HIF-α. This compound exhibits a multi-path anti-fibrosis function and offers renal protection, making it relevant for research into renal anemia. Additionally, it shows potential for investigation in prostate cancer and other cancer types.
- Dual target PROTAC for Smad3 ubiquitination and degradation, and HIF-α protein level improvement.
- Multi-path anti-fibrosis function.
- Renal protection function for research of renal anemia.
- Can be used for research on prostate cancer and other cancers.